ICT for Bio
Biological data modelling, compliance with adopted standards, supervised and unsupervised knowledge extraction.
Molecular profiling, cellular phenotypes characterization, interference, biotechnologies, molecular targets, dynamics of regulatory systems.
Molecular biology, bioinformatics, biostatistics, experimental molecular neurology, molecular medicine, scientific writing.
biological, medical and environmental applications with high technological content.
CRISPR is in the spotlight for sure. The ethics of human-genome editing is to: great power and great responsibility. But let’s see the facts. In April the Huang group at Sun Yat-sen University in China, described their use of the popular CRISPR–Cas9 technology to edit the genomes of human embryos for the first time. This is still the only one published study describing genome editing of human germ cells. But Cas9 is not the only one around: Feng Zhang of the Broad Institute of MIT and Harvard in Cambridge, MA, reported the discovery of Cpf1, a protein that also allows to edit genomes easily. In 2015 several high-profile investors, including the Bill & Melinda Gates Foundation and Google Ventures, invested about $120 million into Editas Medicine, the genome editing firm of Cambridge, Massachusetts. Kevin Esvelt, an evolutionary engineer at the Wyss Institute for Biologically Inspired Engineering at Harvard University in Boston, says “If anyone messes up and a gene drive gets out into the wild, there will be a huge media circus. The message will be that scientists cannot be trusted to deal with this technology, and we will be set back by years. I’m not saying it shouldn’t be done, but it would require some thoughtful modelling”. But, most importantly, do you actually know how to pronounce the word CRISPR? I eventually do…
Cells for breakfast: how microenvironmental autophagy works in tumor growth
Researcher from Norway, Hungary and USA demonstrated that transformed cells engage surrounding normal cells as active and essential microenvironmental contributors to early tumour growth through nutrient-generating autophagy
Good News for cartilage repair!
New data published on a combination of collagen-based scaffold and bioactive factors capable of inducing chondrogenic differentiation of adipose-derived mesenchymal stem cells
Ectopic implantation of cell-free collagen-hydroxyapatite scaffold in the mouse produces bone formation
Results of an in vivo study indicate that bone augmentation and angiogenesis could spontaneously occur into the biomaterial, probably by the recruitment of host cells, and that the composition of the scaffolds is crucial. Collagen-hydroxyapatite scaffolds could represent a promising tool for the reconstruction of large bone defects, without using exogenous living cells or growth factors